跳到主要內容區

龔紘毅 教授

龔紘毅 龔紘毅 教授
學歷:國防醫學院生命科學研究所博士 (Graduate Institute of Life Sciences, National Defense Medical Center, R.O.C.)
研究領域:分子遺傳學、海洋生物技術、分子細胞生物學 (Molecular Genetics, Marine Biotechnology, Molecular Cell Biology)
研究室:生命科學院館R512 / 海洋分子遺傳暨生技研究室 (Marine Molecular Genetics and Biotechnology Laboratory)
電話:02-24622192 分機 5224
E-mail:hygong@mail.ntou.edu.tw
網站:https://www.researchgate.net/profile/Hong-Yi_Gong
發表期刊
  1. Gong HY*, Wu SH, Chen CY, Huang CW, Lu JK, Chou HY. (2017). Complete genome sequence of Streptococcus iniae 89353, a virulent strain isolated from diseased tilapia in Taiwan. Genome Announc. 5(4):e01524-16. 
  2. Wu SH, Lin HJ, Lin WF, Wu JL and Gong HY*. (2018). A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. Fish & Shellfish Immunology 75: 74-90. (SCIE) *Corresponding author
  3. Hsu TH, Lee HT, Chen JY, Gong HY, Huang CW*. (2018). Development of microsatellite multiplex PCR assays for the black seabream (Acanthopagrus schlegelii). J. Fish. Soc. Taiwan 45(2): 65-75.
  4. Chu PY, Kuan JH, TunCC, Hsu TH, Gong HY, Lin CH, Huang CW*. (2018). Establishment of a Database of Microsatellite Markers for the Yellowfin Seabream (Acanthopagrus latus) in the Coastal Sea of Taiwan. J. Fish. Soc. Taiwan 45(2): 59-64.
  5. Wu SH, Chou HY, Liu PC, Wu JL, and Gong HY*. (2019). Granulin peptide GRN-41 of Mozambique tilapia is a novel antimicrobial peptide against Vibrio species. Biochemical and Biophysical Research Communications 515: 706-711. (SCIE) * Corresponding author
  6. Hsu TH, Huang CW, Lee HT, Kuo YH, Liu KM, Lin CH, Gong HY*. (2020). Population genetic analysis for stock enhancement of silver sea bream (Rhabdosargus sarba) in Taiwan. Fishes 5: 19. (SCIE) *Corresponding author
  7. Chiang KY, WC Lin, Tsai TY, Lin CW, Huang SJ, Huang CY, Wu SH, Ken CF, Gong HY*, Chen JY*, Wu JL*. (2020). Dual expression of transgenic delta-5 and delta-6 desaturase in tilapia alters gut microbiota and enhances resistance to Vibrio vulnificus infection. PLoS ONE 15(7): e0236601. (SCIE) *Corresponding author
  8. Kadiene EU, Ouddane B, Gong HY, Kim MS, Lee JS, Pan YJ, Hwang JS*, Souissi S*. (2020). Differential gene expression profile of male and female copepods in response to cadmium exposure. Ecotoxicology and Environmental Safety 204: 111048. (SCIE)
  9. Hsu TH, Chiu YT, Lee HT, Gong HY, Huang CW.* (2021). Development of EST-molecular markers from RNA sequencing for genetic management and identification of growth traits in potato grouper (Epinephelus tukula). Biology (Basel) 10(1):36. (SCIE)
  10. Chiang KY, Li WY, Li YH, Huang SJ, Wu CL, Gong HY, Wu JL*. (2021). Progranulin A promotes compensatory hepatocyte proliferation via HGF/c-met signaling after partial hepatectomy in zebrafish. International Journal of Molecular Sciences 22(20), 11217. (SCIE)
  11. Trung NB, Nan FH, Lee MC, Loh JY, Gong HY, Lu MW, Hang HT, Lin YL, Lee PT*. (2021). Fish-specific TLR18 in Nile tilapia (Oreochromis niloticus) recruits MyD88 and TRIF to induce expression of effectors in NF-κB and IFN pathways in melanomacrophages. Fish & Shellfish Immunology 119, 587-601. (SCIE)
  12. Chu PY, Li JX, Hsu TH, Gong HY, Lin CY, Wang CY, Huang CW*. (2021). Identification of genes related to cold tolerance and novel genetic markers for molecular breeding in Taiwan tilapia (Oreochromis spp.) via transcriptome analysis. Animals (Basel) 11, 3538. (SCIE)
  13. Chen CC, Huang CW, Lin CY, Ho CH, Pham HN, Hsu TH, Lin TT, Chen RH, Yang SD, Chang CI, Gong HY*. (2022). Development of disease-resistance-associated microsatellite DNA markers for selective breeding of tilapia (Oreochromis spp.) farmed in Taiwan. Genes (Basel) 13(1), 99. (SCIE) *Corresponding author
  14. Kadiene EU, Ouddane B, Gong HY, Hwang JS*, Souissi S*. (2022). Multigenerational study of life history traits, bioaccumulation, and molecular responses of Pseudodiaptomus annandalei to cadmium. Ecotoxicology and Environmental Safety 230, 113171. (SCIE)
  15. Hsu TH, Lee HT, Lu HJ, Liao CH, Gong HY, Huang CW*. (2022). Maintenance of genetic diversity of black sea bream despite unmonitored and large-scale hatchery releases. Biology (Basel) 11, 554. (SCIE)
  16. Chu WK, Huang SC, Chang CF, Wu JL and Gong HY*. (2023). Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing. Frontiers in Genetics 14:1029200. (SCIE) *Corresponding author
  17. Hsu TH, Chu PY, Gong HY, Nan FH, Huang CW*. (2023). Utilizing ISSRseq genotyping to assist growth selection in tomato grouper (Cephalopholis sonnerati) without broodstocks information. Journal of the World Aquaculture Society 55, e13035. (SCIE)
  18. Huang CW, Chu PY, Chiang CP, Chang YC, Chu WK, Hsu TH, Gong HY, Wu JL. (2023). Molecular breeding progress in aquaculture species for genomic and sustainable innovation. J. Fish. Soc. Taiwan 50, 1-13.
  19. Yang YC, Chu PY, Chen CC, Yang WC, Hsu TH, Gong HY, Liao IC, Huang CW. (2024). Transcriptomic insights and the development of microsatellite markers to assess genetic diversity in the broodstock management of Litopenaeus stylirostris. Animals (Basel) 14,1685. (SCIE)
  20. Chen CC, Lin CY, Lu HY, Liou CH, Ho YN, Huang CW, Zhang ZF, Kao CH, Yang WC, Gong HY*. (2024). Transcriptomics and gut microbiome analysis of the edible herb Bidens pilosa as a functional feed additive to promote growth and metabolism in tilapia (Oreochromis spp.). BMC Genomics 25, 785. (SCIE) *Corresponding author
  21. Hou WW, Chang YT, Yang WC, Gong HY, Pan YJ, Hsu TH, Huang CW*. (2024). Enhancing the color and stress tolerance of cherry shrimp (Neocaridina davidi var. red) using astaxanthin and Bidens pilosa. PLoS ONE 19, e0315585. (SCIE)
  22. Chiang CP, Huang YS, Chu PY, Guo FJ, Hou WW, Hsu TH, Gong HY, Huang CW.*(2025). Development and Application of Functional Gene-Based SSR Markers for Enhancing Color and Genetic Stability in Taiwan Red Tilapia (Oreochromis spp.). Aquaculture 599, 742089. (SCIE)
  23. Chu WK, Huang SC, Chang CF, Wu JL, and Gong HY*. (2025). Migration of primordial germ cells and their relationship of PGCs with sex development in transgenic germline-specific fluorescent freshwater angelfish (Pterophyllum scalare). Scientific Reports 15, 1308. (SCIE) *Corresponding author
  24. Chu WK, Huang SC, Chang CF, YH Lin, Wu JL, and Gong HY*. (2025). Knockout of dead end 1 by CRISPR/Cas9 leads to loss of germ cells and male-biased sex development in freshwater angelfish (Pterophyllum scalare). Aquaculture 599, 742180. (SCIE) *Corresponding author
  25. Chen CC, Chen YP, Yang HT, Chen YL, Wu CW, Gong HY, Ho YS, Ho YN*. (2025). Temperature-dependent shifts in gut microbiota and metabolome of olive flounder (Paralichthys olivaceus): Implications for cold-water aquaculture expansion and probiotic applications. Animal Microbiome 7, 49. (SCIE)
  26. Chu PY, Hsu TH, Gong HY, Huang CW.* (2025). Molecular decoding of color strains in freshwater ornamental shrimp (Neocaridina spp.) through a dual-marker strategy. J. Fish. Soc. Taiwan 52(2), 39-52.
  27. Chou TC, Lu A, Lin YY, Wu CC, Wong HW, Yik HF, Liao BK, Gong HY, Pan YJ*. (2026). Captive breeding and early development of tank-reared lyretail anthias Pseudanthias squamipinnis (Peters, 1855): assessments of hatching success, larval survival, and ontogeny. Aquaculture 613, 743447. (SCIE)

專書章節:

  1. 黃章文*、徐德華、龔紘毅(2020)。吳郭魚(台灣鯛)基因體分子標記輔助選育技術之研發與應用。前瞻基因體學技術於農業領域之研發應用與展望。(ISBN978-986-5452-17-9 )第110~125頁。台灣台北市:國立臺灣大學動植物農業產業創新領域教學推動中心。
  2. 龔紘毅*、朱慧君、林彥宏、吳金洌。(2023)。第一章第七節 基因編輯技術在水產精準育種之應用。教育部精準健康產業跨領域人才培育計畫專書:精準育種科技之應用及發展。第141-161頁。出版單位:國立中興大學精準農業教學推動中心。ISBN978-986-96453-6-2 20231月出版。*Corresponding author
  3. 黃章文*龔紘毅、徐德華。(2023)。第四章第五節 前瞻基因體與轉錄體定序分子育種技術輔助水產優質種原重要經濟性狀科學化精準選育之應用及發展潛力。教育部精準健康產業跨領域人才培育計畫專書:精準育種科技之應用及發展。第416-421頁。出版單位:國立中興大學精準農業教學推動中心。ISBN978-986-96453-6-2 20231月出版。
  4. 徐德華*、李宏泰、黃章文、龔紘毅(2023)。第四章第七節 次世代分子標記於水產經濟物種的開發與應用。教育部精準健康產業跨領域人才培育計畫專書:精準育種科技之應用及發展。第439-447頁。出版單位:國立中興大學精準農業教學推動中心。ISBN978-986-96453-6-2 20231月出版。
  5. 王榮華*、黃章文、龔紘毅、徐德華。(2024)第六章 人工智慧於水產養殖之應用。第二節 AI 技術於魚類行為姿態及智慧箱網養殖的研究應用。人工智慧科技於農業應用實務。第302-321頁。教育部精準健康產業跨領域人才培育計畫- 國立中興大學精準農業教學推動中心出版。出版年月:20241月。初版。ISBN 978-986-964-538-6PDF)、ISBN 978-986-96453-9-3(平裝)。
  6. Huang CW*, Hsu TH, Gong HY. (2025). Chapter 7 Genomic and Transcriptomic Molecular Markers Assisted Selection of Quality-Based Taiwan Tilapia Breed. P119-151. Tilapia and its Aquaculture in Taiwan. Edited by I Chiu Liao and Eduardo M. Leano. 253 pages. First edition published by WAS, AFS, NTOU, and FST in 2025/05. ISBN: 9786269871445.
  7. Gong HY*, Chu WK, Zeng CA, Huang TY, Yu JH, Huang CW, Hsu TH, Wu JL. (2025). Chapter 8 Advancing Aquaculture Breeding: The Potential of Genome Editing in Precision Breeding of Tilapia and Aquatic Organisms. P153-182. Tilapia and its Aquaculture in Taiwan. Edited by I Chiu Liao and Eduardo M. Leano. 253 pages. First edition published by WAS, AFS, NTOU, and FST in 2025/05. ISBN: 9786269871445. *Corresponding author

 

發明專利:

  1. 龔紘毅、陳鳴泉、吳金洌、黃士晉。新穎肌肉增強子序列及其應用(A NOVEL MUSCLE ENHANCER SEQUENCE AND APPLICATIONS THEREOF)。中華民國發明專利。專利證號:發明第 I 402343號。申請日: 2011/1/20。專利期間: 2013/7/21~ 2031/1/19。申請人:國立臺灣海洋大學。
  2. 龔紘毅、陳鳴泉、吳金洌、黃士晉。肌肉增強子序列及其應用(A MUSCLE ENHANCER SEQUENCE AND APPLICATIONS THEREOF)。中國發明專利 (証書號 1369854)。專利號:ZL 201110221498.0。授權公告日: 2014/03/26。專利期間:2014/03/26~2031/08/02。申請人:龔紘毅。專利權轉讓于台灣海洋大學。
  3. 黃章文、徐德華、龔紘毅、王榮華、黃仁傑。水產生物水面漂浮互動式感測系統及其方法(INTERACTIVE WATER SURFACE FLOATING SENSOR SYSTEM FOR AQUATIC CREATURES AND METHOD THEREOF)。中華民國發明專利 I708558, 申請人:國立臺灣海洋大學。專利期間:2020/11/1~ 2039/05/23
  4. 黃章文、徐德華、龔紘毅、王榮華、黃仁傑、張忠誠。智能型水產生物自動篩選與分級系統及其方法(INTELLIGENT SYSTEM FOR AUTOMATICALLY CLASSIFYING AND GRADING AQUATIC CREATURES, AND METHOD THEREOF)。中華民國發明專利 I708550, 申請人:國立臺灣海洋大學。專利期間: 2020/11/1~2039/7/18
  5. 黃章文、徐德華、龔紘毅、王榮華、黃仁傑、張忠誠。智能型水產生物自動收集與分離系統及其方法(INTELLIGENT SYSTEM FOR AUTOMATICALLY COLLECTING AND ISOLATING AQUATIC CREATURES, AND METHOD THEREOF)。中華民國發明專利 I708640, 申請人:國立臺灣海洋大學。專利期間:2020/11/01~ 2039/07/18
  6. 黃章文、徐德華、龔紘毅、王榮華、黃仁傑、張忠誠。智能型水產生物產卵床系統及其操作方法(INTELLIGENT SPAWNING BED SYSTEM FOR AQUATIC CREATURES AND OPERATION METHOD THEREOF)。中華民國發明專利 I708554, 申請人:國立臺灣海洋大學。專利期間:2020/11/1~ 2039/06/05
  7. 黃章文、徐德華、龔紘毅。魚體或其精巢之全部或部分冷凍保存方法及其系統(CRYOPRESERVATION METHOD AND SYSTEM FOR FISHES OR PART OR ALL OF TESTIS THEREOF)。中華民國發明專利 I723373, 申請人:國立臺灣海洋大學。專利期間:2021/04/012039/04/11
  8. 徐德華、李宏泰、廖正信、黃章文、龔紘毅。循環式環境中微生物或生物分子收集系統及其方法(CIRCULATING TYPE MICROORGANISM OR BIOMOLECULE COLLECTING SYSTEM AND METHOD THEREOF FOR ENVIRONMENT)。中華民國發明專利 I728559。申請人:國立臺灣海洋大學。專利期間:2021/05/21~2039/11/19
  9. 黃章文、徐德華、龔紘毅、王榮華、黃仁傑。水產生物水下互動式感測系統及其方法(INTERACTIVE UNDERWATER SENSOR SYSTEM FOR AQUATIC CREATURES AND METHOD THEREOF)。中華民國發明專利 I757602。申請人:國立臺灣海洋大學。專利期間:2022/03/112039/05/23
  10. 廖正信、李宏泰、徐德華、黃章文、龔紘毅、何攖寧、潘彥儒。過濾式水體生物特徵樣本採集方法及其系統(FILTERING TYPE BIOLOGICAL SAMPLE COLLECTION METHOD AND SYSTEM FOR WATER)。中華民國發明專利I780479。申請人:國立臺灣海洋大學。專利期間:2022/10/11-2040/09/07
  11. 廖正信、李宏泰、徐德華、黃章文、 龔紘毅、何攖寧、潘彥儒。磁吸式水體生物特徵樣本採集方法及其系統(MAGNETIC EXTRACTION TYPE BIOLOGICAL SAMPLE COLLECTION METHOD AND SYSTEM FOR WATER)。中華民國發明專利I780480。申請人:國立臺灣海洋大學。專利期間:2022/10/11-2040/09/07
  12. 徐德華、李宏泰、廖正信、黃章文、龔紘毅。環境中微生物或生物分子收集系統及其方法(MICROORGANISM OR BIOMOLECULE COLLECTING SYSTEM AND METHOD THEREOF FOR ENVIRONMENT)。中華民國發明專利I804695。申請人:國立臺灣海洋大學。專利期間:2023/06/11-2039/11/19
  13. 徐德華、李宏泰、龔紘毅、黃章文。水產生物及水產品之外源性分子追溯方法及其系統(EXOGENOUS BIOMOLECULAR TRACING METHOD AND SYSTEM THEREOF FOR AQUATIC CREATURES AND PRODUCTS)。中華民國發明專利I840799。申請人:國立臺灣海洋大學。專利期間:2024/05/01~2042/05/01
  14. 黃章文、徐德華、龔紘毅。台灣鯛品系之分子特徵鑑別方法及其系統(BIOMOLECULAR CHARACTERISTIC IDENTIFICATION METHOD AND SYSTEM THEREOF FOR TAIWAN TILAPIA STRAINS)。中華民國發明專利I857296。申請人:國立臺灣海洋大學。專利期間:2024/10/01~2042/05/01

 

技轉:

  1. 龔紘毅。新穎肌肉專一性表現單元應用於建立基因轉殖螢光觀賞魚:技術移轉「芝林企業有限公司」。五年非專屬授權(2012/ 04/16~2017/04/15)。
  2. 龔紘毅。吳郭魚先天免疫調節胜肽OmGRN-41以增強魚類抗病存活率技術:技術移轉「全興國際水產股份有限公司」。五年非專屬授權(2012/12/26 ~2017/12/25)。
  3. 龔紘毅。顯微注射法建立基因轉殖螢光神仙魚品系及多轉基因插入位點鑑定技術技術移轉「芝林生物科技股份有限公司」。五年非專屬授權(2014/02/11~2019/02/10)。 
  4. 龔紘毅。抗病與成長性狀功能性基因標記資料庫技術移轉「基育生物科技股份有限公司」。兩年非專屬授權(2020/06/29~ 2022/06/28)。
  5. 龔紘毅。重要經濟性狀數據蒐集與基因標記鑑定技術技術移轉「聖鯛水產科技有限公司 」。兩年非專屬授權(2023/01/01~ 2024/12/31)。
登入成功